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320952

Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Dermatology, venereology and andrology

Abstract

Premature graying of hair (PGH) is a commonly known condition causing significant psychological stress and cosmetic disfigurement. There is unclear significant data available on the clinical profile and pathogenesis. PGH is caused by various exogenous and endogenous factors. There are many causative factors genetic or heredity, oxidative stress from ultraviolet rays, pollution, emotional factors, and inflammatory causes. Also, other environmental factors , drugs, smoking, trace elements, and nutritional deficiency, may play a role in PHG Autophagy may play a significant role in PGH. Many factors have been established to explain the etiopathogenesis of PGH, yet the exact mechanism is still unclear. Also, many treatment modalities have been applied with unsatisfactory results. This review article aims to optimize the most recent and accepted concepts on etiopathogenesis and pathophysiology of PGH and the relation between autophagy and its corresponding genes which may help in finding the best lines of management with the most satisfactory outcomes.

DOI

10.21608/smj.2023.227935.1407

Keywords

Premature graying of hair, etiopathogenesis, autophagy

Authors

First Name

Dina

Last Name

Ali

MiddleName

Ayman

Affiliation

Dermatology, medicine, sohag university, sohag, egypt

Email

dinaayman92@gmail.com

City

Sohag

Orcid

-

First Name

Wafaa

Last Name

Abdelmaged

MiddleName

Mohamed

Affiliation

Department of dermatology, venereology and andrology, faculty of medicine, sohag university, sohag, Egypt

Email

wafaaderm78@yahoo.com

City

Sohag

Orcid

0000-0002-3328-1976

First Name

khaleda

Last Name

amr

MiddleName

-

Affiliation

EgyptMedical Molecular Genetics Department, Human Genetics & Genome Research Division (HGGR), National Research Centre (NRC), Cairo 12622, Egypt

Email

khalda_nrc@yahoo.com

City

Cairo

Orcid

-

First Name

Amr

Last Name

Abdel Hamid

MiddleName

Abdelhamed

Affiliation

Department of dermatology, venereology and andrology, Faculty of medicine, Sohag university, Sohag, Egypt

Email

dramr80@yahoo.com

City

Sohag

Orcid

-

First Name

hoda

Last Name

ahmed

MiddleName

-

Affiliation

EgyptMedical Molecular Genetics Department, Human Genetics & Genome Research Division (HGGR), National Research Centre (NRC), Cairo 12622, Egypt

Email

hoda_radwan80@yahoo.com

City

Cairo

Orcid

-

Volume

28

Article Issue

1

Related Issue

43544

Issue Date

2024-01-01

Receive Date

2023-08-26

Publish Date

2024-01-01

Page Start

6

Page End

10

Print ISSN

1687-8353

Online ISSN

2682-4159

Article File

SMJ_Volume 28_Issue 1_Pages 6-10.pdf

PDF . 478.8kB

Link

https://smj.journals.ekb.eg/article_320952.html

Detail API

https://smj.journals.ekb.eg/service?article_code=320952

Order

320,952

Type

Review Article

Type Code

2,807

Publication Type

Journal

Publication Title

Sohag Medical Journal

Publication Link

https://smj.journals.ekb.eg/

MainTitle

Role of autophagy in the Title aetiopathogenesis of premature graying of hair: a narrative review of literature

Details

Type

Article

Created At

24 Dec 2024