Abstract

Objective: The research attempted to assess the susceptibility of TRAIL polymorphism (rs1131580) in T2DM and its relationship with metabolic parameters in T2DM.

Patients and Methods: This study was performed on 80 subjects, 60 patients with type 2 diabetes mellitus and age & sex matched 20 healthy volunteers as controls, The patients had complete clinical examination and detailed history (duration of diabetes, family history of diabetes and presence of complications) collection, and detection of TRAIL single nucleotide polymorphism rs1131580 by PCR-RFLP standing for polymerase chain reaction-restriction fragment length polymorphism..

Results: TRAIL SNP rs1131580 mutation was greatly more common in the group of diabetics when compared to the control group.

Conclusion: A homozygous variant allele (CC) genotype of the TRAIL SNP rs1131580 carries a 1.5-fold risk of DM. Also, having the C allele elevated the risk of T2DM by 1.7 times.

Keywords: Tumor necrosis factor-related apoptosis-inducing ligand, PCR-RFLP, Type 2 diabetes mellitus.