Introduction: Postoperative sensitivity after a composite restoration is a common concern in dental procedures that causes discomfort in the patient and inconvenience to the professional, especially when dealing with deep caries lesions. Aim: The aim of the study was to prepare and synthesize a fluoride varnish containing silver nanoparticles, and to evaluate the postoperative hypersensitivity after partial caries removal with application of nanosilver fluoride, and silver diamine fluoride in deep caries. Materials and methods: Active deep carious dentinal lesions in permanent teeth from thirty-six participants were included in the study and randomly allocated according to the material used into three groups; nanosilver fluoride, silver diamine fluoride and control. Teeth were isolated by rubber dam, access was done followed by partial caries removal. For the pulpal floor, soft dentine was left to prevent pulp exposure. Silver diamine fluoride or nanosilver fluoride were applied, and all teeth were restored using composite resin restoration. Patients were recalled after 1 week, 3 and 6 months for follow up. Postoperative hypersensitivity was measured using a visual analog scale. Results: The results showed that there was no statistically significant difference in the reported hypersensitivity between the three study groups at the three measured time points. Conclusion: It may be concluded within the scope of this study the postoperative hypersensitivity was not affected by placement of different lining material used in the study after partial removal of caries.