Introduction: The success of a ceramic restoration depends mainly on the nature, quality, and durability of the ceramic resin bond. Aim: This study aimed to compare the shear bond strength of two ceramic materials to adhesive resin cement. Material & Methods: Ten rectangular-shaped samples were cut from two ceramic materials (Zirconia reinforced lithium silicate (Celtra Duo) and monolithic translucent zirconia (Prettau Anterior)) using a low-speed cutting saw under copious water irrigation. Five large samples (12x14x3mm) and another five small samples (7x6x3mm). The large samples were embedded in epoxy resin blocks. Each ceramic material underwen t surface treatment according to the manufacturer's instructions. The bonded surfaces of Celtra Duo samples were etched with 9% hydrofluoric acid for 20 seconds and then Clearfill ceramic primer plus was applied. While the bonded surfaces of Prettau Anterior samples were sandblasted using 110 μm AL2O3 particles under 2.5 bar pressure for 15 seconds, then the Clearfill ceramic primer plus was applied. Finally, the large samples were bonded to their corresponding smaller samples of the same material using Panavia v5 cement. A Computerized universal testing machine was used to evaluate the shear bond strength. Each sample was firmly attached to the lower fixed compartment of the machine. A mono beveled chisel edge metal blade was attached to the underside of the upper movable compartment of the testing machine to apply compressive shear load parallel and as close as possible to the bonded interface at a cross head speed of 0.5 mm/min. Results: Results showed that the Celtra Duo samples had a statistically significantly higher shear bond strength to Panavia V5 adhesive cement (17.132±0.431MPa) than that of Prettau Anterior zirconia  (14.046±0.488 MPa). Data were analyzed by independent sample t-test one at p ≤ 0.05. Conclusions: The shear bond strength of the ceramic material bonded to resin cement was affected by the type of ceramic and surface treatment.