Introduction: Over the past century, craniometric measurements have been considered of great significance in the field of dentistry, especially in the field of orthodontics and orthognathic surgery. Over the last decade, the usage of Cone Beam Computed Tomography (CBCT) has tremendously escalated to overcome the drawbacks of 2D imaging techniques.  accordingly, it has been the focus of many studies to evaluate the accuracy of this radiographic technique in obtaining linear skull measurements.
Aim: The aim of this study was to determine the reliability of linear measurements obtained from CBCT in comparison to direct skull measurements. 
Materials and Methods: This study was conducted on twelve dry human skulls. Three direct horizontal linear parameters were obtained between certain identified landmarks on each skull using a digital caliper. The skulls were subjected to CBCT examination. The measurements were obtained from CBCT 3D Volume Rendering (3D VR) images, then compared to the real skull measurements and statistically assessed for accuracy.
Results: The results of the current study revealed very good intra and inter-observer agreement regarding all the assessed linear measurements obtained from gold standard and CBCT scans. In addition, CBCT showed non-significant underestimated values with difference ranging from (-0.13 mm, -0.10 %) to (-0.32 mm, -0.34 %) in comparison to direct skull measurements (gold standard).
Conclusion: Linear measurements derived from CBCT are accurate and reliable and can be confidently used for different maxillofacial clinical applications especially in orthodontics.