ABSTRACT
Introduction: Dental caries is a specific disease caused by long-term contact between the host, diet, and microorganisms on the tooth surface. This causes the inorganic parts of the enamel and dentin to break down. Aim: This study aimed to assess the clinical and radiological effectiveness of using Simvastatin in combination with Biodentine as a pulpotomy  agent for vital primary molars. Materials and Methods: sixty primary molars in 20 children aged from 4-7 years old were selected from Outpatient Clinic of Pediatric Dentistry Department, Faculty of Dentistry, Suez Canal University and randomly allocated to three groups, Biodentine, Simvastatin and combination of Biodentine and simvastatin. All treated teeth were clinically evaluated at (1M,3Ms,6Ms,9Ms,12Ms) for presence of pain, tender on percussion, swelling/sinus or pathological tooth mobility and evaluated radiographically at (3Ms,6Ms,9Ms,12Ms) for loss of lamina dura, widening in periodontal ligament space presence of external/internal resorption or presence of periapical /furcation radiolucency. Result: The overall success rate was 100%, 5%, and 90% for Biodentine, Simvastatin, and the combination of Biodentine and Simvastatin groups, respectively. After a year of follow-up, the groups had a highly significant difference in overall success rates.
Conclusion: After one year follow up Our findings demonstrated remarkable results of combination of Biodentine and simvastatin in pulpotomy of primary teeth. Therefore, combination of Biodentine and simvastatin may be considered as an effective material in pulpotomy of primary teeth because of its successful results. While Simvastatin showed failure clinically and radiographically.
Clinical Trial Registration: Registered on ClinicalTrials.gov under identifier number: NCT05582317, Protocol Record 2020-293, https://clinicaltrials.gov/ct2/show/ NCT05582317.