This research aimed at examining the direct impact of digital transformation on sustainable development at the Private hospitals in the governorates of Lower Egypt and exploring whether development of HRM practices play a mediating role in this relationship. The research began with a literature review of digital transformation, sustainable development development of HRM practices followed by developing a conceptual framework and formulating four main hypotheses. A field study was then conducted using a sample of 384 employee working at all administrative levels (Top, Middle, executive) at the Private hospitals in the governorates of Lower Egypt and the number of completed questionnaires is 375. Collected data were analyzed using the Structural Equation Modeling. Statistical results revealed that all dimensions of the digital transformation (Building DT Strategy, Spreading DT Culture, Human Dimension, procedural Dimension, technical Dimension) have a statistically significant positive direct impact on dimensions of Sustainable development that can be measured by three dimensions (Economic, Social, Environmental) at the Private hospitals in the governorates of Lower Egypt. Regarding the direct impact of digital transformation dimensions on development of HRM practices (recruitment, selection, training &development, compensation system, performance management), it was found that all dimensions of digital transformation have a statistically significant positive direct impact on development of HRM practices. Moreover, Statistical results also revealed that development of HRM practices have statistically significant direct impact on sustainable development dimensions. Finally, regarding the mediation of development of HRM practices, findings showed that development of HRM practices play a mediating role in the relationship between digital transformation dimensions and sustainable development dimensions at the Private hospitals in the governorates of Lower Egypt.