Three-dimensional printed buildings offer numerous advantages compared to traditional construction methods. They provide higher efficiency and faster execution, contributing to reduced time and effort in the construction process. Additionally, they can be designed and built using recyclable and environmentally friendly materials, promoting environmental sustainability and cost reduction. They can be engineered to withstand earthquakes and natural disasters and possess the capability to address current environmental challenges such as climate change and the energy crisis. The aim of this research is to develop an applied scientific methodology for the design and implementation of three-dimensional printed buildings using recyclable and environmentally friendly materials in Egypt. This will be achieved by leveraging a comparative scientific approach that studies global and regional experiments in this field, with the objective of adapting and implementing this methodology in Egypt, particularly in special regions like Siwa Oasis. The research will also utilize artificial intelligence applications and mathematical equations to enhance outcomes and achieve success in this advanced and innovative field