Objective of current explore is to determine protective effect of baobab plant (Adansonia digitata) and metformin by examining several biochemical and biochemical indicators on the kidneys and liver of rats treated with alloxan to induce diabetes. Seventy adult Albino rats divided to 7 groups: The study involved diabetic rats in different groups, each receiving different treatments. The control group received alloxan monohydrate, while the group with Baobab received 500 mg/kg orally. The group with metformin received 100 mg/kg orally. The treatments were administered orally for 15 and 30 days. The baobab intake, alone or in conjunction with metformin, on different parameters in a diabetic animal model. The results looked good. Treatment with baobab has improved renal function, as demonstrated by lower urea and creatine levels. Lipid profile research revealed a decrease in triglyceride levels as well as fluctuations in HDL and cholesterol levels, all of which have a good effect on lipid control. In conclusion D.M. in male rats increased kidney function markers and hepatic enzymes, but baobab plant treatment reduced these levels, indicating potential to mitigate adverse effects and increase beneficial fat levels.