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Investigation of the Ameliorating Effect of Copper Albumin Complex on Lysyl oxidase in monosodium iodoacetate -Induced Knee Osteoarthritis in Rats

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Last updated: 24 Dec 2024

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Abstract

Knee osteoarthritis (KOA) is a common type of joint degeneration which causes progressive damage of the joint structure and has less therapeutic options. It has been found that oral consumption of Copper Albumin Complex as anti-inflammatory drug has a positive effect on the treatment of joint deterioration. The present study aimed to investigate the effect of oral administration of Copper Albumin Complex (cu-albumin complex) on Lysyl oxidase (LOX) which acts as a protective factor in KOA. Fifty adult albino rats were divided into 3 groups: negative control (10 normal rats); positive control (20 rats with KOA which left without induction treatment); and treated group (20 rats with KOA which treated with administration of copper albumin complex). Treated and untreated arthritic groups were subdivided equally into mild and severe groups (10 rats for each) according to the severity of clinical signs. KOA was induced by intra-articular injection of monosodium iodoacetate (MIA). At the experimental end, the joints were examined histopathologically and immunohistochemically after cervical dislocation of rats. It was observed that the treatment with CU- was effective in reducing disease severity and in improvement of Lysyl oxidase KOA. It was concluded that Copper albumin complex has a positive effect in the improvement of LOX of Knee joint cartilages of rats affected by osteoarthritis (OA).

DOI

10.21608/svu.2022.155864.1222

Keywords

knee, osteoarthritis, Lysyl oxidase, Copper-albumen complex, cartilage

Authors

First Name

Olaa M.

Last Name

Galal

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt

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-

Orcid

-

First Name

Nashwa A. M.

Last Name

Mostafa

MiddleName

-

Affiliation

Department of histology and cell biology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Asmaa A.

Last Name

Metwally

MiddleName

-

Affiliation

Surgery department, Aswan University, A3Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528 Aswan

Email

asmaaabdelsalam104@yahoo.com

City

Aswan, Egypt

Orcid

0000000185658220

First Name

Reham I. El-Mahdy

Last Name

El-Mahdy

MiddleName

-

Affiliation

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University, Egypt.

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-

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-

Orcid

-

First Name

Ahmed Y.

Last Name

Nassar

MiddleName

-

Affiliation

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed S.

Last Name

Abdallah

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Abdelsabour-khalaf

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt

Email

m_sabour@vet.svu.edu.eg

City

-

Orcid

0000-0002-9551-0075

First Name

ahmed

Last Name

abdeen

MiddleName

-

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt

Email

ahmed.abdeen@fvtm.bu.edu.eg

City

benha

Orcid

-

First Name

Samer S.

Last Name

Fouad

MiddleName

-

Affiliation

PhD in Veterinary Clinical Pathology, Qena University Hospital, South Valley University, Qena 83523, Egypt.

Email

samer.saad80@yahoo.com

City

-

Orcid

-

First Name

Magdy M.

Last Name

Slama

MiddleName

-

Affiliation

Medical biochemistry, Faculty of Medicine, Al-azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Obeid

Last Name

Shanab

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt

Email

shanab.bio@vet.svu.edu.eg

City

-

Orcid

0000-0003-1981-279X

Volume

6

Article Issue

1

Related Issue

38532

Issue Date

2023-03-01

Receive Date

2022-08-12

Publish Date

2023-03-01

Page Start

18

Page End

30

Print ISSN

2535-1826

Online ISSN

2535-1877

Article File

SVU_Volume 6_Issue 1_Pages 18-30.pdf

PDF . 416.2kB

Link

https://svu.journals.ekb.eg/article_292150.html

Detail API

https://svu.journals.ekb.eg/service?article_code=292150

Order

292,150

Type

Research article

Type Code

712

Publication Type

Journal

Publication Title

SVU-International Journal of Veterinary Sciences

Publication Link

https://svu.journals.ekb.eg/

MainTitle

Investigation of the Ameliorating Effect of Copper Albumin Complex on Lysyl oxidase in monosodium iodoacetate -Induced Knee Osteoarthritis in Rats

Details

Type

Article

Created At

24 Dec 2024