Background: Perceived patient satisfaction is one indicator to measure quality of the nursing care. Purpose: The present study aimed to assess patient's satisfaction towards nursing care quality in Najran Hospitals at Najran city southern of Saudi Arabia. Methods: A descriptive cross sectional study design was conducted between Octobers to December 2019. The sample of the study consisted of 333 patients who admitted to the different hospital departments and voluntarily agree to partake in the study. Data were collected using a standardized questionnaire (Patient Satisfaction with Nursing Care Quality Questionnaire (PSNCQQ). It is rated on a 5-point Likert scale. The collected data were analyzed by statistical Package for social sciences (SPSS) version 23. Results: Of 333 participants in the present study. The main finding revealed that the proportion of overall satisfaction toward quality of nursing care was 250(75.08%) of participant were satisfied and 83 (24.92%) of participants were dissatisfied. Male patient 165(66.5%) more satisfied with nursing care than female 83(33.5). Married patient more satisfied 173(69.2%) than single 41(16.4%).Patient with digestive disorders and fractures and patients in surgical ward showed more satisfaction approximately (75%). Also patients admitted one time 100(40%) are more satisfaction than patient who admitted two times 80(32%) , three times 39(15.65) and four times or more 30(12%). Conclusion: Three quarter of patients were satisfied with nursing care they received in Najran hospitals and there is a higher significant association between satisfaction of patient and marital status, number of admission to hospital and ward they admitted in and diagnosis, recommendations: Implement quality improvement initiatives based on the identified areas of patient dissatisfaction, further studies in large population are recommended to ensure continuity of care and generalization of findings.