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MYOSTATIN AS A POTENTIAL DIAGNOSTIC BIOMARKER IN ELDERLY PATIENTS WITH SARCOPENIA

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Last updated: 03 Jan 2025

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Abstract

Sarcopenia is a progressive loss of skeletal muscle mass and strength. Myostatin is a myokine, and a potent negative regulator of muscle growth. This study aimed to assess the accuracy of serum myostatin in prediction of Sarcopenia in elderly patients and correlate it with QoL. The study involved 64 elderly patients aged 65 years and older; Group (I):32 sarcopenic patients, and Group (II):32 healthy age and sex-matched control participants. Participants with chronic renal, hepatic, or cardiac compensation, DM, women on hormonal replacement therapy were excluded. All participants were subjected to history taking, clinical examination, anthropocentric measurements, routine laboratory investigations, serum myostatin using ELISA, and SF-36 to assess QoL. Sarcopenia was diagnosed using EWGSOP-2 criteria. Sarcopenic patients had significantly lower ASMI, hand grip strength, and physical performance values (p<0.001). Serum Myostatin level in sarcopenic patients was significantly higher compared to controls (32.73 ± 5.0 vs. 26.49 ± 6.44 IU/dl) (p<0.001). Sarcopenic patients had significantly lower scores of SF-36 score compared to the controls (74.19 ± 5.04 vs 84.84 ± 3.33) (p<0.001).A significant negative correlation was found between serum myostatin and SF-36 scores in the sarcopenic group compared to the control group (r= -0.345; p<0.001).Serum myostatin level more than 29 (IU/dl) has sensitivity of (87.5%) and specificity of (75%) in discriminating sarcopenic patients from healthy elders. In conclusion; serum myostatin is a possible blood-based biomarker for Sarcopenia prediction as well as quality of life assessment in such population. Further researches with more sample sizes are required to confirm our outcomes.

DOI

10.21608/niles.2024.275569.1081

Keywords

loss of muscle mass and function, quality of life, Elders, negative regulators of skeletal muscles

Authors

First Name

marwa

Last Name

saad

MiddleName

-

Affiliation

professor of internal medicine, Geriatric unite, Internal Medicine department, faculty of medicine , Alexandria university

Email

drmarwasaad74@gmail.com

City

Alexandria, Egypt

Orcid

0000-0002-8177-1055

First Name

Sekina

Last Name

Ahmed

MiddleName

-

Affiliation

Geriatric unit, Internal Medicine Department, Faculty of Medicine, Alexandria university,

Email

sekina.ahmed0000@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Abdelmajeed

MiddleName

-

Affiliation

Internal medicine department, General Navy Hospital

Email

dr.mahmoudabdelrahman89@gmail.com

City

-

Orcid

0009-0006-4536-4256

First Name

Reham

Last Name

Aboelwafa

MiddleName

-

Affiliation

clinical and chemical pathology, Faculty of medicine, Alexandria university

Email

reham.abdelhalem@alexmed.edu.eg

City

Alexandria, Egypt

Orcid

0000-0003-2113-3569

First Name

Doaa

Last Name

Genena

MiddleName

Mounir Mahmoud

Affiliation

Department of nutrition and public health,Institute of Medical Research, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Rana

Last Name

Emara

MiddleName

-

Affiliation

Lecturer of Nutrition, High Institute of Public Health, Faculty of Medicine, Alexandria university

Email

ranaemara@alexu.edu.eg

City

-

Orcid

0000-0001-6575-8902

Volume

7

Article Issue

2

Related Issue

42290

Issue Date

2024-07-01

Receive Date

2024-03-08

Publish Date

2024-07-01

Page Start

321

Page End

339

Print ISSN

2636-3224

Online ISSN

2636-3232

Link

https://niles.journals.ekb.eg/article_345866.html

Detail API

https://niles.journals.ekb.eg/service?article_code=345866

Order

2

Type

Original Article

Type Code

695

Publication Type

Journal

Publication Title

NILES journal for Geriatric and Gerontology

Publication Link

https://niles.journals.ekb.eg/

MainTitle

MYOSTATIN AS A POTENTIAL DIAGNOSTIC BIOMARKER IN ELDERLY PATIENTS WITH SARCOPENIA

Details

Type

Article

Created At

24 Dec 2024