The study investigates the technological characteristics of some Egyptian cotton varieties, under planting seasons, location, and their interactions. It aims to evaluate how variations in cultivation locations and seasons impact the observed differences in fiber attributes, as well as how the studied varieties adapt to diverse environmental conditions. The study also investigates the interaction between different growing seasons and locations and its effects on the varieties under scrutiny. A randomized block design (RCBD) with four replications was used during two seasons (2018 and 2019) at multiple locations across Egypt, including El-Behira, El-Munofeya, El-Gharbia, Kafr El-Sheikh, El-Dakahlia, El-Sharkeya, Beni Suef, Fayoum, and El-Menya. Results indicate significant variations in fiber properties influenced by seasonal variations and specific growth locations, highlighting the importance of considering these factors in cotton cultivation practices. Results revealed significant influences of seasonal changes on traits such as strength, elongation, and spinning consistency index (SCI) for Giza 86 and Giza 94, while Giza 95 primarily showed effects on short fiber index and neps count. Furthermore, varying growth locations exhibited differential effects on specific traits of Giza 86, with notable variations observed in fiber maturity and strength across locations. Additionally, the interaction between cultivation season and growth location significantly influenced fiber traits, highlighting the importance of considering both factors in cotton cultivation.