The current study was conducted on twelve-year-old 'Le-Conte' pear trees plants budded on 'Butialefola' pear rootstock, planted in sandy soil under drip irrigation in a private Farm located at El-Nubaria, EL-Beheira Governorate, Egypt, throughout 2021 and 2022 season, to study the effect of foliar application of putrescine at 20, 40 and 60 ppm, and glycine betaine at 30, 60 and 90 compared to water only as a control. The trees were also sprayed by 250 ppm Fe + 250 ppm Zn + 250 ppm Mn + 100 ppm H₃BO₃, 500 ppm Fe + 500 ppm Zn + 500 ppm Mn + 200 ppm H₃BO₃ and 750 ppm Fe + 750 ppm Zn + 750 ppm Mn + 300 ppm H₃BO₃ on vegetative growth, and leaf mineral content from macro and micronutrients of 'Le-Conte' pear trees. Fifty uniform trees were chosen for this investigation, and they were subjected to identical cultural practices throughout seasonal times. Five replicates for each treatment were organized in a randomized complete block design (RCBD). The treatments were sprayed three times at; swollen buds, 15 days later and the third spray was 30 days after the second one. The results showed that foliar application of putrescine increased shoot length, thickness, leaf area, and leaf total chlorophyll content, followed by spraying of glycine betaine and certain micronutrient treatments. Sprayed treatments considerably also enhanced the leaf mineral contents of nitrogen, phosphorus, and potassium, iron, zinc, manganese, and boron.