During the main cropping season of 2019, the experiment was conducted in the Koundoul city of Chad, at longitude (35'' 58' 11˚ N) and latitude (00'' 09' 15˚ E). This study included only Sorghum bicolor L. plant type (Abo Drisha) that was treated with neem leaves and seeds powders in addition to dry cow manure. The treatments were grouped according to the randomized complete block design (RCBD) in three replicates, using plastic bags. The results of our experiment explained that the treatment with dry cow manure alone significantly (5% level) improves the growth and productivity characteristics of Sorghum seeds, which are represented by the length of the plant (107cm), number of leaves (16 L/P), leaf surface area (657dm²), weight of 100 grains (208g), number of grains (2469) and their weight (41g) in one kernel, and the dry weight of shoot (47g), compared to other treatments. Our results also showed that the treatment with dry cow manure and powder of dried neem leaves recorded the lowest significant value (100%) in the flowering stage which reached 83 days from the date of planting, while the treatment with a mixture including dry cow manure and the powder of dried neem leaves and seeds achieved the highest significant levels for the kernel weight and its perimeter as 108g and 24cm, respectively. It also recorded the lowest significant value for the number of Striga hermonthica parasites (5 p), their height (27cm), their branch number (3b), and their dry weight (12g). The present study concluded that using a mixture of dried cow manure with powdered neem leaves and seeds is the most effective inhibitor of S. hermonthica, while dry cow manure is the best fertilizer for seeds, therefore, we recommend using this mixture as a powder to control the spread of parasites and using dry cow manure as an organic fertilizer for S. bicolor.