Spot form net blotch (SFNB) disease has been seriously limiting barley production in Tigray. As a result, there is a need to enhance barley production through the development of management options that can be effectively used in combating the SFNB problem. This research was conducted to evaluate the effect of Thiram and propiconazole on the severity of SFNB of barley. The experiment was conducted using a split-plot design with three replications. The cultivars included: HB-1307, HB-42, Fetina, and saesea were used. The fungicides were thiram and propiconazole as main plots and varieties are the sup plots respectively. The data were subjected to ANOVA using GenStat version 2018 software. HB-42 was found resistant while saesea was susceptible. The highest area under the disease progress curve (AUDPC) was recorded in untreated saesea (1517.7). The minimum AUDPC of SFNB (536.9) was in HB-42 with the spray of fungicides. The highest yield was in Fetina with sprayed (4.02 ton/ha) and the lowest was untreated HB-42 (2.288 ton /ha). Fetina with a spray of Thiram and Propiconazole in comparison with the unsprayed offered 2383.42% of the marginal rate of return so Fetina with the spray of Thiram and Propiconazole is recommended for profitable production.