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296702

Frequency of Multi-Drug Resistant Enterobacter Species Isolated from Patients with Different Clinical Manifestations in Khartoum State, Sudan

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Last updated: 24 Dec 2024

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Abstract

Enterobacter species are members of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) which are described as the leading cause of resistant nosocomial infections.Objectives: The present study aimed to estimate the frequency of Multi-Drug resistant Enterobacter species isolated from Patients with different Clinical manifestations in Khartoum state, Sudan.Methods: A cross-sectional laboratory-based study was conducted from February 2021 to October 2021. To isolate and identify Enterobacter species from different clinical specimens by conventional cultural methods, and to determine the antimicrobial profile of Enterobacter species by Kirby–Bauer disc diffusion technique.Result: A total of three hundred and eighty-four (n=384) different clinical specimens (urine 232(60%), wound swab 61 (16%), sputum 19(5%), and blood 72 (19%) specimens were collected from Yastabshiroon Hospital, Khartoum, 129(33.6%), Ribat Teaching Hospital, Khartoum, 255(66.4%), 173 (45.0%) were from males, while 212 (55.0%) from females, among 154(40%) bacterial isolate 22(14.3%) were identified as Enterobacter spp. All Enterobacter spp isolates (100%) were multidrug resistant, The Prevalence rates of resistance of the isolates among antibiotic classes were as follows; (Penicillin 100%, Cephalosporin 96.4%, Tetracycline group 100%, Aminoglycosides 47.7%, Sulfonamides and trimethoprin 86.4%, Nitrofuran 100%, Quinolone 72.75%, Glycopeptides 100%, Chloramphnicol 100%, Tetracycline 81.8% and Carbapenem 52.3%).Conclusion: This study is the first study reporting the frequency of Multi-drug resistance Enterobacter species in Sudan. The results of this study indicated the high prevalence of Enterobacter species resistant to the majority of assessed antibiotics, and high prevalence rates of carbapenemase and ESBL-producing Enterobacter species In Khartoum- Sudan.

DOI

10.21608/eajbsg.2023.296702

Keywords

Enterobacter, Antimicrobial susceptibility, MDR, ESBLs, carbapenemase producing Enterobacter

Authors

First Name

Hiba

Last Name

Mahgoub

MiddleName

Abdel Salam Ahmed

Affiliation

Department of Medical Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan.

Email

hibaam24@hotmail.com

City

-

Orcid

-

First Name

Tyseer

Last Name

Mahgoub

MiddleName

A.A.

Affiliation

Fetomaternal center-Doha-Qatar

Email

tyseer-mahgoub@hotmail.com

City

Qater

Orcid

-

First Name

Osama

Last Name

Khair

MiddleName

M. M.

Affiliation

National University Biomedical Institute, National University, Sudan. -Oczon Laboratory of Molecular Biology, Khartoum, Sudan.

Email

-

City

Sudan

Orcid

-

First Name

Mawada

Last Name

Mohammed

MiddleName

H.F.

Affiliation

Department of Medical Microbiology, Yastabshiroon Hospital, Sudan

Email

-

City

Sudan

Orcid

-

First Name

Maye

Last Name

Merghani

MiddleName

M.

Affiliation

Medical Laboratory Science program, AlNahda College, Sudan.

Email

may.mohammed.m@gmail.com

City

Sudan

Orcid

0000-0003-2806-9931

First Name

Majdolin

Last Name

AlBushra

MiddleName

I.M.

Affiliation

Medical Laboratory Science program, AlNahda College, Sudan.

Email

majdolinibrahim22@gmail.com

City

Sudan

Orcid

-

First Name

Elsadig

Last Name

Hamdan

MiddleName

M.

Affiliation

Department of Medical Microbiology, College of Medical Laboratory Science, University of Gezira, Sudan.

Email

elsadighamdan@yahoo.com

City

Sudan

Orcid

-

First Name

Hisham

Last Name

Altyab

MiddleName

N.

Affiliation

Department of Medical Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan -Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah 21452, Saudi Arabia

Email

hishamaltayb@gmail.com

City

Saudi Arabia

Orcid

0000-0002-2635-9383

First Name

Hind

Last Name

Ahmed

MiddleName

H.

Affiliation

Department of Medical Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan.

Email

hindhaidar011@gmail.com

City

Sudan

Orcid

0000-0001-7747-515X

First Name

Mogahid

Last Name

Elhassan

MiddleName

M.

Affiliation

Department of Medical Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan-Nahrain College, Khartoum, Sudan.

Email

-

City

Sudan

Orcid

-

Volume

15

Article Issue

1

Related Issue

38907

Issue Date

2023-06-01

Receive Date

2023-02-27

Publish Date

2023-04-11

Page Start

129

Page End

140

Print ISSN

2090-0872

Online ISSN

2090-0880

Article File

EAJBSG_Volume 15_Issue 1_Pages 129-140.pdf

PDF . 833.1kB

Link

https://eajbsg.journals.ekb.eg/article_296702.html

Detail API

https://eajbsg.journals.ekb.eg/service?article_code=296702

Order

296,702

Type

Original Article

Type Code

689

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, G. Microbiology

Publication Link

https://eajbsg.journals.ekb.eg/

MainTitle

Frequency of Multi-Drug Resistant Enterobacter Species Isolated from Patients with Different Clinical Manifestations in Khartoum State, Sudan

Details

Type

Article

Created At

24 Dec 2024