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392634

Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Oral histology

Abstract

Dental mesenchymal stem cells (MSCs) have emerged as a promising therapeutic avenue for tissue regeneration in regenerative medicine. While cellular transplantation of MSCs has shown potential for achieving functional tissue regeneration, several clinical challenges hinder its implementation. An alternative approach, harnessing the secretome of MSCs, has gained attention as a cell-free therapeutic strategy. The secretome encompasses the bioactive molecules released by MSCs, which have been shown to exert profound effects on tissue regeneration. This review comprehensively analyzes the dental MSCs secretome, understanding the potential of the MSCs secretome, addressing the obstacles associated with its utilization, and its potential as a valuable resource for regenerative therapies. In summary, the secretome of dental MSCs holds great promise as a cell-free therapeutic strategy for tissue regeneration. This review highlights the importance of further research and standardization efforts to fully exploit the therapeutic potential of the MSCs secretome and realize its clinical translation in regenerative medicine.

DOI

10.21608/adjc.2024.299756.1575

Keywords

Dental mesenchymal stem cells, Secretome, cell-free therapy, tissue regeneration

Authors

First Name

Sara

Last Name

El Moshy

MiddleName

-

Affiliation

Department of Oral Biology, Faculty of Dentistry, Cairo University, Egypt

Email

sarah.mahmoud@dentistry.cu.edu.eg

City

-

Orcid

0000-0002-2860-8523

First Name

Dina

Last Name

Rady

MiddleName

-

Affiliation

Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt

Email

dina.radi@dentistry.cu.edu.eg

City

-

Orcid

-

First Name

Israa

Last Name

Radwan

MiddleName

Ahmed

Affiliation

Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt

Email

esraa.ahmed@dentistry.cu.edu.eg

City

-

Orcid

-

First Name

Marwa

Last Name

Abbass

MiddleName

MS

Affiliation

Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt

Email

marwa.magdy@dentistry.cu.edu.eg

City

-

Orcid

0000-0002-6455-7516

First Name

Aiah

Last Name

El-Rashidy

MiddleName

A.

Affiliation

Faculty of Dentistry, Cairo University

Email

aiah.abdelwahab@dentistry.cu.edu.eg

City

Cairo

Orcid

0000-0002-4475-0837

First Name

Khadiga

Last Name

Sadek

MiddleName

M.

Affiliation

Biomaterials Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Email

khadiga.sadek@dentistry.cu.edu.eg

City

-

Orcid

-

First Name

Geraldine

Last Name

Ahmed

MiddleName

Mohamed

Affiliation

Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt

Email

geraldine.ahmed@dentistry.cu.edu.eg

City

-

Orcid

-

First Name

Eman

Last Name

Abouauf

MiddleName

Ali

Affiliation

conservative Dentistry, Faculty of Dentistry Cairo University

Email

e.abouauf@dentistry.cu.edu.eg

City

-

Orcid

0000-0002-1764-1600

First Name

nermeen

Last Name

AbuBakr

MiddleName

Mohamed

Affiliation

Oral Biology Department, Faculty of Dentistry, Cairo University.

Email

nermeen.abubakr@dentistry.cu.edu.eg

City

-

Orcid

0000-0003-2962-0070

First Name

Al-Hassan

Last Name

Wadan

MiddleName

Soliman

Affiliation

Sinai University, Faculty of Dentistry, Arish Branch, North Sinai, Egypt

Email

amohamed6521@su.edu.eg

City

-

Orcid

-

First Name

Christof

Last Name

Dörfer

MiddleName

E.

Affiliation

Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany

Email

doerfer@konspar.uni-kiel.de

City

-

Orcid

-

First Name

Karim

Last Name

Fawzy

MiddleName

-

Affiliation

Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt

Email

karim.fawzy@dentistry.cu.edu.eg

City

-

Orcid

0000-0002-6261-3609

Volume

6

Article Issue

4

Related Issue

50701

Issue Date

2024-10-01

Receive Date

2024-06-30

Publish Date

2024-10-01

Page Start

889

Page End

917

Print ISSN

2636-302X

Online ISSN

2636-3038

Article File

ADJC_Volume 6_Issue 4_Pages 889-917.pdf

PDF . 1.1MB

Link

https://adjc.journals.ekb.eg/article_392634.html

Detail API

https://adjc.journals.ekb.eg/service?article_code=392634

Order

392,634

Type

Review Article

Type Code

691

Publication Type

Journal

Publication Title

Advanced Dental Journal

Publication Link

https://adjc.journals.ekb.eg/

MainTitle

Dental Mesenchymal Stem Cell Secretome: A Cell-free Therapeutic Approach for Tissue Regeneration

Details

Type

Article

Created At

24 Dec 2024