Aim: The aim of the study is to investigate Transforming growth factor beta immune-expression in oral papillary squamous cell carcinoma and then compare its expression in oral squamous cell carcinoma with different histological grade to correlate its expression with the prognosis. Subjects and methods: This will be accomplished by collecting archival blocks of oral papillary squamous cell carcinoma and oral squamous cell carcinoma with different histological grades, then staining the specimens with transforming growth factor beta, and then calculating the area percent for each group. Results: Results showed that the epithelial expression of transforming growth factor beta was significantly high in well differentiated squamous cell carcinoma with statistically significant results. On the contrary, there was no difference in the epithelial expression of transforming growth factor beta between oral papillary squamous cell carcinoma, moderately differentiated and poorly differentiated cases with statistically insignificant results. Transforming growth factor beta showed the highest expression in the stroma of poorly differentiated squamous cell carcinoma with statistically insignificance results with the other three groups. Conclusion: Oral papillary squamous cell carcinoma may has a favorable prognosis than well differentiated squamous cell carcinoma.