Aim of the study: The purpose of this study is to compare the efficacy of infrared light and laser therapy as myofascial pain treatment modalities (immediate or delayed effect). Material and methodology: 80 Female Patients with an age range from 16 to 50 years, selected from the out-patient clinic of the oral and maxillofacial department, faculty of dentistry, Cairo University; with myofascial pain or taut fascial painful trigger points were involved in this study from April 2022 to April 2023. 1st group was treated with low-level laser therapy while the 2nd group was treated with infrared lamp therapy. Results: immediate improvement in both groups, while in the follow-up period, the laser group showed more improvement in the pain and mouth opening measurements. Discussion and conclusion: Although our research has shown that these two techniques may relieve myofascial trigger points, there are limited clinical trials proving that they are beneficial, time-save, and drug-free. According to the literature, laser therapy is more effective as a non-surgical modality than any other injection technique. A vicious cycle of pain, muscle spasms, and more pain has been said to be broken by enhancing microcirculation through the utilization of laser therapy. This could improve the supply of oxygen to the cells in low-oxygen environments and aid in getting rid of waste products from cell metabolism.