Objectives: This study intended to evaluate the retention and patient satisfaction of two different denture base materials in the maxillary speech obturator in patients with soft palatal defects. Methodology: Ten patients with unilateral hard and soft palate defects were carefully chosen from the Maxillofacial Prosthodontic Unit, Faculty of Oral and Dental Medicine, Cairo University. The patients were randomly divided into two groups. Group I received maxillary speech obturators constructed with soft acrylic applied on the posterior part of the obturator . Group II: received maxillary speech obturators constructed with versacryl applied on the posterior part of the obturator. Results: Regarding to the retention outcomes were revealed that (Group I) showed a statistically significant higher mean retention values than (Group II) in all intervals after 1week of insertion, 1month, 3 months and 6 months . while Regarding to the patient satisfaction results of this study was revealed that (Group I) showed a higher statistically significant mean values of patient satisfaction scores regarding evaluation of the masticatory efficiency , speech evaluation than (Group II) only after 6 month . On the other hand, regarding to stability and comfort evaluations there were non statistically significant difference between the two groups in the whole intervals.