Aim: The aim of this study was to evaluate histologically the effect of biphasic calcium phosphate combined platelet-rich fibrin on bone regeneration in a surgically created bone defect.
Subjects and methods: Sixteen bony surgical defects were created in tibia bone of male white New Zealand rabbits. According to graft material, the surgical defects were divided into two study groups and one control group that left empty without grafting. Study Group (A) was grafted with BCP+PRF, while Study Group (B) was grafted with BCP only. Decapitation was carried out after one month and the grafted defects were dissected and prepared for histological examination.
Results: Both study groups showed better healing compared to the control group which was filled with granulation tissue infiltrated by chronic inflammatory cells. Both grafted groups showed lamellar bone formation filling the defect and extending into the surface in some cases. In group (A), bone trabeculae filling the defect were thicker and mostly mineralized, compared to group (B). In addition, cartilage formation was noticed in group (A).
Conclusion: Biphasic calcium phosphate combined platelet-rich fibrin is a valuable graft material and provide superior quality of bone regeneration and a promising biomaterials in inducing cartilage repair.