Aim: The aim of the study was to evaluate the effect of platelet rich fibrin on the post-operative pain after surgical depigmentation procedure.

Methodology: Twenty-four patients with gingival hyper-pigmentation were recruited and randomly assigned to the control group; using non-eugenol periodontal pack only, or to the test group; using L-PRF with periodontal pack. The gingival depigmentation procedure was done using a combination of scalpel and bur techniques and both groups were covered using the periodontal pack. The post-operative pain was measured using visual analogue scale (VAS) that was tested and compared.

Results: In the control group, 100% of the patients reported pain that ranged from moderate to distressing pain after the 5th day while in the test group 8.3% of the patients reported very mild pain after the 5th day.

Conclusion: Using PRF after gingival depigmentation procedure results in decreased post-operative pain when compared to using non-eugenol containing periodontal packs alone.