Objectives: To compare the remineralization potential of Curodont Repair Fluoride Plus Versus CPP -ACP in management of white spot lesions.
Methodology: 48 white spot lesions in patients received randomly two types of remineralizing agents, either Curodont Repair Flouride Plus (self-assembling peptide p11-4) or MI paste daily use, both materials were applied according to the manufacturer's instructions. White spot lesions were evaluated before and after 1, 4, and 6 months follow up periods by assessors to assess remineralization potential using ICDAS II Criteria and digital photographs using analysis software to get the percentage of white spot lesions. Results: According to ICDAS II, intergroup comparison between both materials have shown no statistically significant difference, Intragroup comparisons within Curodont Repair Fluoride Plus have shown statistically significant difference between different follow-up periods (P < 0.0001). Curodont Repair Fluoride Plus had 25% less risk for (ICDAS 1and 2) than CPP-ACP after 6 months (RR= 0.75, 95% CI, P=0.2498). According to the photographic analysis, Two-way ANOVA revealed statistically significant effect of material and follow-up on WSL % (P<0.001). Conclusions: Curodont Repair Flouride Plus is a biomimetic remineralizing agent that provides a therapeutic option for enamel regeneration. Curodont repair fluoride plus provided a better chance for complete healing of incipient lesions.