This article is intended to reach out to the readers about the potential of marine based bio materials in the field of periodontal regeneration. Periodontal Regeneration is the reproduction or reconstruction of a lost or injured tissue so that the architecture and function of lost or injured tissues are completely restored. Regeneration done using guided tissue regeneration procedures helps in guiding the regeneration of periodontal structures through differential tissue responses. Various types of barrier membranes or bone grafts used for regenerative procedures are autograft, allograft, xenograft and alloplast. Xenografts such as bovine, porcine had been used commonly in the regenerative procedures. Since the bovine derived collagen have higher risk of encephalopathy other sources of collagen have been researched upon. It has been suggested that besides mammalian collagen, fish collagen may have the potential to be used for the development of GTR/GBR. In order to overcome the shortcomings in the collagen and improve the regenerative potential, researches are being done with the addition of various bioactive substances in the field of regenerative materials such as natural polymer- chitosan, hydroxyapatite ceramics as in scaffolds, nanofibers etc.