Introduction: Hyperglycemia is a major complication of diabetes mellitus (DM), a disease of glucose metabolism that associated with major organ damage. Aim of the work: The goal was to compare the preventative effects of curcumin versus combination of losartan and captopril medication on rats' liver damage from type I diabetic. Material and methods: Fresh streptozotocin (STZ) solution, dissolved in sodium citrate buffer, was utilized by a single intraperitoneal injection (50 mg/kg body weight) to induce diabetes mellitus in rats within 15 minutes of formulation. Study groups were control group, diabetic group, diabetic group treated with captopril/losartan (C/L+D), diabetic group treated with curcumin (Cur+D), each group contains 6 randomly distributed rats. Blood samples were used to detect liver enzymes and assess markers of oxidative stress, also, paraffin liver sections were taken. Results: STZ-induced diabetic inflammation and apoptotic effects were better ameliorated by curcumin, while the combination of captopril and losartan was better in healing STZ-induced diabetic fibrosis. Recommendation:  To improve biochemical and histopathological results, three drug combinations (captopril, losartan and curcumin) should be tested.