Background: Systemic lupus erythematosus (SLE) is an autoimmune illness with uncertain cause that manifests itself clinically and laboratory as organ involvement with remission and return. Lupus nephritis (LN) is an immune complex glomerulonephritis that arises because of SLE in around 50% of patients. The neutrophil lymphocyte ratio (NLR) has been identified as an inflammatory marker. Also Mean platelet volume (MPV) has also been studied in chronic inflammatory disorders, implying that MPV and NLR might be employed as inflammatory indicators in LN. Objective: to investigate the role of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as inflammatory markers for occurrence of lupus nephritis. Methodology: This was a case control study conducted in Al-Zahraa University hospital on 60 patients diagnosed as SLE, 30 with lupus nephritis and 30 were controls. All patients were subjected to detailed history taking, physical examination, laboratory investigations for CBC, MPV, NLR, ESR, CRP, Serum creatinine, Serum urea, Serum uric acid, Serum albumin and the GFR was calculated. Results: The mean age of the LN group was 27.4 ± 4.9 and 27.6 ± 4.7 for patients without lupus nephritis. The mean MPV was 10.3 ± 1.2 in cases with LN and 8.1 ± 0.5 in cases without LN. The NLR was 5.9 and ranged between 3.04 and 18.9 in cases with LN while in cases without NL, the mean NLR was 1.6 and ranged between 1.05 and 2.9 indicating that there was high significant difference between the 2 groups regarding MPV and NLR. NLR is positively correlated to platelet lymphocyte ratio (PLR). Both MPV and NLR values fail to correlate with any inflammatory markers in LN patients. Conclusion: MPV and NLR could be used to predict LN but not as inflammatory markers in those patients.