Introduction: Chronic kidney disease in children   (CKiD)  represents a major global health issue that is becoming more and more common. It burdens the child and his family. Their quality of life (QoL) is impacted.
Aim of the study: to assess the quality of life (QOL) of children with end-stage renal disease (ESRD) and their mothers.
Methods: This study was carried out in Pediatric Nephrology Unit at Assuit university Hospital on 35 child with ESRD on regular hemodialysis and their mothers. Using WHOQOL-BREF, Peds QL-ESRD and Parental Stress Scale .in a period from May 2022 to May 2023.
Results: According to Peds QL-ESRD, there is low quality of life in all of  its domains, with  children  ≥ 12 years have higher  quality of life than younger children  in the worry domain with significant p- value (=0.049). As regard  duration of dialysis, children on dialysis more than one year had  higher  quality of life than those less than one year. Mothers of children   with ESRD show low quality of life according to WHOQOL-BREF. There is a significant difference according to  their   age  in the psychological domain (p value =0.049)and social domain (p- vale < 0.010). Parental Stress Scale  shows  elevated level of stress with significant p-value <0.001. 
Conclusion: Quality of life of children on regular hemodialysis and their mothers  is low in most  aspects. Older children and older  mothers had better  quality of life than younger ones  suggesting that older  experienced mothers  can cope better with their diseased children.  Mothers of ESRD children  have elevated level of stress in general but they are satisfied.