Beta
342876

Evaluation of Endocan Serum Level as a Marker of Cardiovascular Risk in Children on Maintenance Hemodialysis.

Article

Last updated: 24 Dec 2024

Subjects

-

Tags

Dialysis and CRRT.

Abstract

Introduction:  Chronic kidney disease (CKD) patients have a higher risk of premature death, mainly due to cardiovascular reasons. Endocan plays a crucial role in causing endothelial dysfunction and inflammation, which makes it a valuable biomarker for detecting cardiovascular disease prognosis. 
Aim of the study: This study aims to investigate the correlation between Endocan levels in the serum of children undergoing hemodialysis and intimal-medial thickness (IMT) and peak systolic velocity of the main arteries. 
Methods:  A comprehensive analysis was conducted to evaluate serum levels of endocan, intimal medial thickness, and peak systolic velocity using Doppler ultrasound, in addition to routine laboratory investigations.
Results: Children who underwent hemodialysis had higher endocan levels than the control group; the median and (IQR) of endocan serum levels were 144.35 (122.2 – 247.55 pg/ml) and 61 (29.05 – 108.8 pg/ml), respectively (P<0.01). The hemodialysis group showed a significant increase in the intima-media thickness (IMT) of the carotid, ulnar, and femoral arteries. Moreover, there was a substantial decrease in the peak systolic velocity (PSV) of the carotid and ulnar arteries in the hemodialysis group. The study also found a positive correlation between the levels of endocan and C-reactive protein (CRP) and the IMT of the carotid, ulnar, and femoral arteries.
Conclusion: Children undergoing hemodialysis displayed elevated endocan levels, significantly associated with increased IMT in major arteries. Endocan plays a significant role in developing and propagating atherosclerosis, thereby increasing the risk of cardiovascular disease.

DOI

10.21608/geget.2023.342876

Keywords

endocan, Hemodialysis, children, cardiovascular risk

Authors

First Name

Manal

Last Name

Abdelsalam

MiddleName

-

Affiliation

Pediatric Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Email

manal24969@gmail.com

City

Cairo Nasr City Egypt

Orcid

0000-0001-9714-9837

First Name

Aliaa

Last Name

Atef

MiddleName

-

Affiliation

Pediatric Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Email

olaatef54321@gmail.com

City

Cairo Nasr City Egypt

Orcid

-

First Name

Naglaa

Last Name

Fathy

MiddleName

-

Affiliation

Pediatric Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Email

naglaafathi778@gmail.com

City

-

Orcid

-

First Name

Nadia

Last Name

Yousif

MiddleName

-

Affiliation

Clinical Pathology Department, National Heart Institute, Cairo, Egypt.

Email

nadiayriad@yahoo.com

City

-

Orcid

-

First Name

Hala

Last Name

Maghraby

MiddleName

-

Affiliation

Radiology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Email

dr_hala_maghraby@yahoo.com

City

-

Orcid

-

Volume

18

Article Issue

2

Related Issue

46288

Issue Date

2023-12-01

Receive Date

2023-10-29

Publish Date

2023-12-31

Page Start

25

Page End

36

Print ISSN

1687-613X

Online ISSN

2636-3666

Link

https://geget.journals.ekb.eg/article_342876.html

Detail API

https://geget.journals.ekb.eg/service?article_code=342876

Order

342,876

Type

Original Article

Type Code

675

Publication Type

Journal

Publication Title

GEGET

Publication Link

https://geget.journals.ekb.eg/

MainTitle

Evaluation of Endocan Serum Level as a Marker of Cardiovascular Risk in Children on Maintenance Hemodialysis.

Details

Type

Article

Created At

24 Dec 2024