Introduction: The association between urinary abnormalities and allergic diseases was studied, but coincidence of allergy flare-ups with urological manifestations was seldomly discussed.
Aim of study: assess presence of urological manifestations in pediatric patients with various types of allergies and determine change in urological manifestations with allergic activity.
Methods: cross sectional pilot study with nested follow up, conducted in Allergy, Immunology and Rheumatology Clinic, Children's Hospital, our university over 6 months, March 2022 to September 2022. Patients diagnosed as allergy recruited consecutively during routine follow up. All patients screened at time of allergy flare-up for urological symptoms, 50 patients associated with urological symptoms were investigated at time of enrolment and at remission. Investigations included urine analysis, urinary eosinophils, and urinary eosinophilic cationic protein.
Results: Among 193 allergic children, 50 patients, aged 8.04 ± 2.97 years old, 28 (56%) boys and 22 (44%) girls, developed urological symptoms at time of allergy exacerbation (31.6%), 38% had combined forms of allergy. Statistically significant decline of urological manifestations found by time of allergy remission, on allergy controller therapies. Eosinophils were microscopically detectable in the urine of 18 (36%) of the studied patients during allergy flare-up, and not detected by remission. Urinary ECP median level was significantly higher at exacerbation than allergy convalescence.
Conclusion: Urological manifestations commonly associated with allergy flare-up, regardless type of allergy. Presence of urinary eosinophils and elevated levels of urinary ECP at allergy flare ups suggest that urinary system could be targeted by allergens, which needs more elucidation in further studies.