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387169

The Impact of Aqueous Piliostigma thonningii Fruit Extract on Certain Biochemical Parameters on Male Wister Albino Rats

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Last updated: 24 Dec 2024

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Abstract

Introduction: Piliostigma thonningii is a medicinal plant known for its diverse biological activities. This study examined the impact of the aqueous extract of P. thonningii fruits on biochemical parameters in a rat model. Methods: Male Wister Albino rats were administered varying doses (200, 500, and 1000 mg/kg) of the P. thonningii fruit aqueous extract for 28 days. The levels of liver enzymes (AST, ALT, and ALP), total protein, lipids, glucose, and indicators of renal function (urea, creatinine) were evaluated using standard assay kits and colorimetric methods. Results: The fruit aqueous extract of P. thonningii fruit had a significant effect in reducing serum AST levels (p<0.01) at doses of 500 and 1000 mg/kg, and ALT levels (p<0.05) at a dose of 1000 mg/kg. The treated groups exhibited a significant (p<0.05) decrease in total protein and cholesterol. The administration of the highest dose (1000 mg/kg) resulted in a notable decrease (p<0.01) in serum glucose levels, indicating the presence of hypoglycemic characteristics. There were no significant alterations detected in the levels of ALP, urea, and creatinine. Conclusion: The aqueous extract of P. thonningii fruits exhibited favorable positive effects on biochemical parameters in rats, indicating its potential therapeutic applications.

DOI

10.21608/eajbsc.2024.387169

Keywords

biochemical parameters, glucose, Lipid profile, liver function, P. thonningii, and Rat model

Authors

First Name

Somia

Last Name

Agab

MiddleName

A.

Affiliation

Omdurman Islamic University (OIU), Department of Botany, Faculty of Science and Technology, Omdurman, Sudan.

Email

-

City

Sudan

Orcid

-

First Name

Hatil

Last Name

EL-Kamali

MiddleName

H.

Affiliation

Omdurman Islamic University (OIU), Department of Botany, Faculty of Science and Technology, Omdurman, Sudan.

Email

-

City

Sudan

Orcid

-

First Name

Mohamed

Last Name

Ibrahim

MiddleName

AE.M.

Affiliation

Al-Baha University, Department of Public Health, Faculty of Applied Medical Sciences, Al-Baha City, Saudi Arabia.

Email

-

City

Saudi Arabia

Orcid

-

First Name

Azhari

Last Name

Nour

MiddleName

A.

Affiliation

Al-Baha University, Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha, KSA.

Email

azhari1933@gmail.com

City

KSA

Orcid

-

First Name

Meisa

Last Name

Al Foraih

MiddleName

-

Affiliation

Department of Food Science and Nutrition, College of Health Sciences, Public Authority for Applied Education and Training, Shuwaikh Industrial, Kuwait.

Email

-

City

Kuwait.

Orcid

-

First Name

Khalid

Last Name

Kheiralla

MiddleName

E. K.

Affiliation

Al-Baha University, Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha, KSA.

Email

khatahir12@gmail.com

City

ksa

Orcid

-

First Name

Mohammed

Last Name

Shanwaz

MiddleName

A.

Affiliation

Al-Baha University, Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha, KSA.

Email

-

City

KSA

Orcid

-

First Name

Mohamed

Last Name

Elsamani

MiddleName

O.

Affiliation

Al-Baha-University, Department of Chemistry. Faculty of Science P.O. Box-1988, Al-Baha City,65527, KSA.

Email

-

City

KSA

Orcid

-

First Name

Omar

Last Name

Ali

MiddleName

Y.M.

Affiliation

Al-Baha University, Department of Public Health, Faculty of Applied Medical Sciences, Al-Baha City, Saudi Arabia.

Email

-

City

Saudi Arabia

Orcid

-

First Name

Sultan

Last Name

Mashnafi

MiddleName

Q.

Affiliation

Al-Baha University, Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha, KSA.

Email

-

City

KSA.

Orcid

-

First Name

Elgaili

Last Name

Omer

MiddleName

A.

Affiliation

Deanship of Graduated Studies & Scientific Research, Kassala University, Kassala, Sudan.

Email

-

City

Sudan

Orcid

-

Volume

16

Article Issue

2

Related Issue

48899

Issue Date

2024-12-01

Receive Date

2024-09-17

Publish Date

2024-10-24

Page Start

229

Page End

236

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 16_Issue 2_Pages 229-236.pdf

PDF . 444.7kB

Link

https://eajbsc.journals.ekb.eg/article_387169.html

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https://eajbsc.journals.ekb.eg/service?article_code=387169

Order

387,169

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

The Impact of Aqueous Piliostigma thonningii Fruit Extract on Certain Biochemical Parameters on Male Wister Albino Rats

Details

Type

Article

Created At

24 Dec 2024