The development of genome amplification assays has made it possible to describe new foamy viruses (FV) and re-evaluate the part that assists them in transmission to humans causing co-infection. To shed light on the prevalence of simian foamy virus (SFV) in hosts due to the presence of other non-human primates or cattle in nearby regions, this systematic review and meta-analysis was started. Through the databases of Pubmed and Global Index Medicus, we conducted an electronic search. We included observational studies that indicate the presence of zoonotic infection in human population settings related to SFV via cross-species transmission only. The quality of the included articles was evaluated after data extraction. Using a random effect model, we performed analyses on sensitivity, subgroups, publication bias, and heterogeneity. Out of a total of 417 studies retrieved, 12 articles were included in the systematic review. A meta-analysis, performed on 10 studies, revealed a significantly increased risk of SFV transmission in humans due to the bite, scratches, and saliva transmission from non-human primates. Through its analysis of the most recent literature, this study has the advantage of providing public health authorities with useful information about the effectiveness of current precautions against SFV.