Background: The autoimmune-mediated chronic condition known as type 1 diabetes mellitus (T1DM) is typified by the degeneration of the pancreatic β cells that produce insulin.Method: The study included 75 T1DM patients and 25 healthy subjects.Results: Hematological tests which included WBC, RBC, Hb, HCT, MCV, platelets and differential for patients and controls showed significant differences (p<0.05) found in WBC, platelets, neutrophils in patients as compared with the control group, while no significant differences(p>0.05) were found in the results of RBC, Hb, HCT, MCV, lymphocytes between the groups of patients and controls.  The erythrocyte sedimentation rate in patients and the healthy groups, where the results of the study showed a significant increase in ESR (p<0.05) of the patients (25.14±1.59mm/hr) compared with the healthy group (23.83±1.704mm/hr).Biochemical Tests: The results of estimation of the biochemical parameters values showed Significant increases were found in the results of blood sugar in patients as compared with the control group, while no significant differences (p>0.05) were found in the results of creatinine and urea between the patients and controls.Conclusions: According to the current study, compared to the control group, diabetes patients had significantly higher levels (p<0.05) of many inflammatory indicators, including WBC, platelets, neutrophils, and ESR.