A Cross-Sectional study that includes an assessment of the relation of the physiological and immunological factors among postmenopausal women with osteoporosis and heart diseases who attended Samarra General Hospital in    Salah AL-Din Governorate The study started from January 2022 to November 2022 on a study population whose ages ranged from 45-70 years, their total number is 100 women, 25 of whom are healthy women who are considered as a control group, and 75 of them are represented by groups of patients that were distributed into three main groups: 25 women with Heart disease only include myocardial infarction and 25 women with osteoporosis only and 25 women with Heart disease and osteoporosis blood samples were collected from patients and healthy subjects and then serum separated for testing. The present study was designed to obtain more clarification of some Immunological changes in women patients with osteoporosis and heart diseases. and find out the role of some Immunological parameters of pro-inflammatory cytokines like Interleukin – 6 IL-6, Interleukin- 8 IL-8 and C-reactive protein  CRP  in the serum of women patients with osteoporosis and heart diseases the result of  Immunological parameters include: Interleukin-6, Interleukin IL-8 showed had no significant differences (P≥0.05) in a group of osteoporosis in comparison with the control group and showed significantly increased (P≤0.05) in groups of  Heart disease, and osteoporosis with heart disease in comparison with control group. but (CRP) showed a significant increase (P≤0.05) in groups of osteoporosis, Heart disease, and osteoporosis with heart disease in comparison with the control group.
              To investigate the physiological relationship between Immunological parameters,  interleukin 6 and interleukin 8  and high sensitivity C-reactive protein in patients of Osteoporosis and Heart diseases in Samarra city.
             Serum interleukin-6 and Interleukin IL-8 showed no significant differences (P≥0.05) in the group of osteoporosis in comparison with the control group and showed significantly increased (P≤0.05) in groups of  Heart disease, and osteoporosis with heart disease in comparison with the control group , . but (CRP) showed a significant increase (P≤0.05) in groups of osteoporosis, Heart disease, and osteoporosis with heart disease in comparison with the control group.