Purpose: A case-control study was conducted to evaluate the role of protencarponyls and glycemic biomarkers in type two diabetic patients with proliferative diabetic retinopathy (PDR).Materials and Methods: a case-control study includes a comparison between 3 groups, (40 healthy persons ) as a control compared with (40 type-2 diabetic patients without proliferative retinopathy) and (40 diabetic patients with proliferative retinopathy) serum PC were determined with ELISA while glycemic biomarkers FBS, HbA1c was determined by spectrophotometry method ( autoanlyser technique). Result: PC serum level and FBS, HbA1c statistically significantly increased among the study groups, the highest level in PDR patients when compared with control groups and T2M Patients without RP. Conclusion: Protein carbonyls are increased significantly in both T2DM without PDR and PDR patients compared with healthy people ( control ).FBS and HbA1c decreased significantly in both T2DM without PDR and PDR patients compared with healthy people ( control ).