A total of 50 serum samples were collected from patients with Echinococcus granulosus and 38 serum samples from healthy humans were taken from the Al-Furat AL-Awsat Hospital, Maternity and Children Teaching Hospital and Al-Diwaniyah Teaching Hospital in Al-Diwaniyah and from Specialized Hospital for Gastroenterology and Hepatology in AL-Najaf for the period from November 2022 to April 2023. The test was performed on 5 ml of venous blood, which was collected from each sample for an Enzyme-linked immunosorbent assay (ELISA)  test to detect Echinococcosis IgE. The Distribution of Hydatid Cysts according to the site of the infection was the high rate of infection in the liver compared with other organs. The concentration level of IgE was increased in patients compared with the control, with a significant difference at (P ≤ 0.05) while the level of IgE was decreased after the surgery compared with the before the surgery in patients with a significant difference at (P ≤ 0.05). The levels of IgE concentrations in patients according to the location of the cyst were the highest level in the liver.