Five ml blood samples were obtained from fifty recurrent Echinococcosis patients. A total of 50 serum samples were collected from patients with Echinococcus granulosus and 38 serum samples from healthy humans were taken from the Al-Furat AL-Awsat Hospital, Maternity and Children Teaching Hospital and Al-Diwaniyah Teaching Hospital in Al-Diwaniyah and from Specialized Hospital for Gastroenterology and Hepatology in AL-Najaf for the period from November 2022 to April 2023. The test was performed on 5 ml of venous blood, which was collected from each sample for ELISA test to detect the positivity of oxidative stress Glutathione peroxidase (GPX). The clinical assessment of the 50 patients (who confirmed to have Echinococcosis after giving positive results by ELISA) was revealed that the frequency of distribution of patients according to sex was (74%) females and (26%) males. The differences between females and males were statistically significant (P < 0.05, P-value= 0.001). The estimated incidence of Echinococcosis increased in the 21-40 years age group, with a significant difference (P < 0.05) in comparison with the other groups. The Distribution of Hydatid Cysts according to the site of the infection was the high rate of infection in the liver compared to other organs. The concentration level of GPX decreases in patients compared with the control with a significant difference at (P ≤ 0.05). The concentration level of GPX decreased after the surgery compared with the before surgery and after surgery with a significant difference at (P ≤ 0.05).