Background: Thousands of people have already died as a result of the 2019 coronavirus disease pandemic (COVID-19), which was brought on by the SARS-CoV-2 coronavirus. There were many unimaginable cases of illness in Washington in 2020 as a first case, and then it was transmitted to Wuhan, Germany, France, Italy, Spain, the United Kingdom and China. The newly discovered SARS-CoV, MERS-CoV, and SARS-CoV-2 are believed to be natural and not laboratory synthetic. The COVID-19 pandemic may be due to the contamination of infected people and objects with infected materials that spread across the world.Main body: Human COVID-19 infection symptoms can range from being asymptomatic to being fatal, including respiratory failure, multiple organ dysfunction, and death. Large-scale genetic association studies have demonstrated that immune system components such as interferons, interleukins, toll-like receptors, and human leukocyte antigen as well as COVID-19 receptor variations (angiotensin-converting enzymes, transmembrane serine protease-2) are important host determinants of COVID-19 severity. Conclusion: The current review aims to demonstrate the human genetic factors that affect COVID-19 severity.