The chemically banned silver nanoparticles AgNPs were used, whose purity was tested by FESEM device using EDS, and the purity of AgNPs was 97.6. In addition to examining them by means of the dynamic atomic force microscope, which has the ability to take two- and three-dimensional images. For silver nanoparticles AgNPs, which showed sharp bumps up to a height of (15.3 nm) for the protein-coding of the SARS-CoV-2 virus and stopping the (RBD) region from binding to the receptors on the surface of the host cell within the spike protein. The results of the statistical analysis were in the study. The present study is that there is a significant increase between the different concentrations of silver nanoparticles on the outer protein coat, S protein, as it showed a high effect at a concentration of 50 at a rate of 12.23 ± 0.462pg/ml, while the lowest rate was recorded at a concentration of 0.3 at a rate of 0.16 ± 0.11pg/ml, mediated by the rest of the concentrations. In patients with SARS-CoV-2, at a rate of (11.40 ± 0.43, 11.00 ± 0.26, 0.16 ± 0.11, 4.53 ± 0.57, 9.06 ± 0.32, 9.80 ± 0.50, 10.63 ± 0.30), and according to concentrations (25, 12.5 , 6.25,3.12, 1.5, 0.75.).