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321259

A Novel Spectrophotometric Approach for Estimation of Non-steroidal anti-inflammatory drugs (NSAIDs) in Pharmaceutical Drug formulations by Neocuproine

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Last updated: 03 Jan 2025

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Abstract

A novel, simple, accurate, sensitive, reproducible, economical method for spectrophotometric approach for measuring MFA in Pharmaceutical Drug formulations was successfully developed and verified. A novel analytical technique for estimating MFA 250 mg in capsule pharmaceutical formulations for different brands was established. The method suggested is based on the reduction of Cu(II)-2,9DMP complex to colored Cu(I)- 2,9DMP complex. The optimum experimental conditions have been achieved. Beer'ss Law holds true in the concentration levels 5.0-60 μg/mL with accurate molar absorptivity of 0.238 L/mol.cm at 454 nm and “detection limit" was 0.5882 μg/mL and the limit of quantification was 1.7825 μg/mL and correlation coefficient obtained has been near to one. The Effect of pH, reaction time, Buffer Solutions, Volume of Cu(ІІ), Volume of 2,9.DMP reagent, temperature, Order of Addition, and Effect of Acid on the determination of MFA, have been examined. The proposed method has been successfully utilized for quantitative assessment of commercially produced dosage modes. Our research sought to develop a fresh, accurate, and sensitive technique for measuring MFA as a pure pharmacological product and as a hard dosage. The creation of a metal complex of MFA with a copper ion is a prerequisite for the spectrophotometric approach.

DOI

10.21608/eajbsc.2023.321259

Keywords

Spectrophotometric, mefenamic acid (MFA), Neocuproine (2, 9.DMP), ponistan

Authors

First Name

Ali

Last Name

Nayef

MiddleName

Naser

Affiliation

Department of Chemistry, College of Science-University of Kerbala, Kerbala, Iraq.

Email

alielli100@gmail.com

City

Iraq

Orcid

-

First Name

Alaa

Last Name

Hussain

MiddleName

Fark

Affiliation

Department of Chemistry, College of Science-University of Kerbala, Kerbala, Iraq.

Email

-

City

Iraq

Orcid

-

First Name

Dakhil

Last Name

Taha

MiddleName

Nassir

Affiliation

Specialized Medical Sciences, University College of Al-Amal, Karbala 56001, Iraq.

Email

-

City

Iraq

Orcid

-

Volume

15

Article Issue

2

Related Issue

42345

Issue Date

2023-12-01

Receive Date

2023-09-02

Publish Date

2023-10-18

Page Start

443

Page End

452

Print ISSN

2090-0767

Online ISSN

2090-083X

Link

https://eajbsc.journals.ekb.eg/article_321259.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=321259

Order

321,259

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

A Novel Spectrophotometric Approach for Estimation of Non-steroidal anti-inflammatory drugs (NSAIDs) in Pharmaceutical Drug formulations by Neocuproine

Details

Type

Article

Created At

24 Dec 2024