Background: Breast cancer is the most common type of cancer in women, with one to eight women developing breast cancer in their lifetime. This study aims to investigate the effect of invasive ductal carcinoma on some physiological and immunological parameters in women with breast cancer.The methods: The current study at the National Cancer Centre in Al-Najaf province for the period between 8/15/2022 to 1/20/2023. this study included 60 women with breast cancer considered as the patients and 30 healthy women free of diseases considered a control group, both groups, their ages ranged between (30-68) years old, body mass index, erythrocyte sedimentation rate, C-reactive protein, iron stores (ferritin) and fetal carcinoembryonic antigen were estimated.Results: The results showed that invasive ductal carcinoma is the most prevalent type of breast cancer with a rate of 68.7% within the studied sample.  As for metastasis, it was noted that stage 0 was the highest with a rate of 96.7%.  The results of the disease stage also showed that stage 2 was the highest with a rate of 73.3%.  The results showed an increase in body mass index (BMI) in the control group compared to the patients' group.  A significant increase in the erythrocyte sedimentation rate (ESR) was also observed in women with breast cancer compared with the group of healthy women. The results of the statistical analysis also showed a significant increase in iron stores (Ferritin), CRP and CEA among the affected women compared with the healthy women.
            The results showed that there were no significant differences in the type of invasive ductal carcinoma compared to the invasive lobular carcinoma for the criteria represented by body mass index, and erythrocyte sedimentation rate.  As for the levels of ferritin, C-reactive protein and CEA, the results of the statistical analysis showed that there was a significant increase in their levels in patients with invasive lobular carcinoma compared with the other group with invasive ductal carcinoma.
                       The results also showed that there is an effect of the type of disease ((invasive ductal carcinoma)) on each of the erythrocyte sedimentation rate and CEA.Conclusions: the results obtained through the current study, we conclude that invasive ductal carcinoma is the most common type of breast cancer with an increase of ESR, CRP, ferritin and CEA in women with breast cancer. The effect of invasive ductal carcinoma on CEA and ESR criteria was more than invasive lobular carcinoma.