Osteoporosis is a silent disease because bone loss occurs without symptoms, this disease is regarded one of the most health problems for women at menopause, it results in rapid loss of bone density. this research included a case-control study to know the prevalence of osteoporosis in Iraqi menopausal women. One hundred women patients visit Al-Sader teaching hospital in AL-Najaf province /Iraq to determine the percentage of bone density using a dual-energy x-ray absorptiometry (DEXA), Blood samples were taken after diagnosis of the disease. In addition, serum calcium, and phosphorous were measured by spectrophotometer, while serum (PTH, and Dikkopf_1) were measured by enzyme-linked immune sorbent assay (ELISA). Data were gathered by direct interviews with the women. The study excluded those who had chronic diseases. This study showed a significant increase (p< 0.05) in the concentration of Dikkopf_1 and a reduction in the concentration of serum calcium and phosphorus in osteopenia and osteoporotic menopausal women compared with control group. The current study also showed a significant increase (p< 0.05) in the levels of parathyroid hormone in menopausal women with osteoporosis compared with control group. In conclusion, increasing serum (Dikkopf_1) levels in postmenopausal women with osteoporosis play an important role in the development of primary osteoporosis.