Many studies have found effects on the body and active products insulin state at near and long-term parameters in end-stage renal disease (ESRD) patients. Consequently, studying chemical molecules that cause tissue damage to kidneys is essential for understanding the mechanism of effect and available treatment prospects. Which includes some factors of insulin, Homeostasis Model Assessment insulin sensitivity (HOMA2%IR), Homeostasis Model Assessment sensitivity for cell (HOMA2%S), Homeostasis Model Assessment state beta cell function (HOMA2%B) parameters. The published papers on changes in the effects of IR products of patients were reviewed, and the explanations obtained from previous research were collected. It is concluded from this review that causes an increase in parameters in patients with ESRD leads to neurodegeneration and disorders affect the beta cell to produce insulin, which leads to severe damage to patients health that requires therapeutic intervention to reduce the harmful effects of parameters on the health of patients.