Rheumatoid arthritis (RA), an autoimmune condition, is the most prevalent inflammatory arthropathy worldwide. Egypt's RA phenotypic spectrum varies from region to region, with a progressive shift in the F:M ratio. Limited studies have explored the correlation between lncRNA HOTTIP single nucleotide polymorphisms (SNPs) and RA. This study aimed to evaluate the genetic association of single nucleotide polymorphism rs3807598 (C:G) of HOTTIP among rheumatoid arthritis patients. Method: The study included 120 subjects from 2 groups: 60 RA patients and 60 healthy controls. Real-time PCR with TaqMan allelic discrimination assay was used to perform the genotyping. The odds ratios (ORs) models and 95% confidence interval (CIs) were used to test the associations. Results: The results indicated that lncRNA HOTTIP SNP rs3807598 (C:G) exhibited a statistically nonsignificant association with the risk of RA. Conclusion: Up-to-date, the role of HOTTIP SNPs in RA risk is still unknown, It is important to consider how epigenetic modifications including non-coding RNAs polymorphism and expression affect the RA risk and how well it responds to treatment.  Further studies, with a larger sample size, could highlight more significant relations between SNPs of non-coding RNAs and RA.