Background and objectives: The incidence rates of papillary thyroid cancer have increased over the past three decades. We aim to establish an epidemiological profile of papillary thyroid cancer, collect additional data about clinical and etiological features, and highlight how the disease is managed in Northwestern Algeria.Patients and Methods: An epidemiological retrospective descriptive study was conducted at the nuclear medicine department of the Anti-Cancer Center in Sidi Bel Abbes region (western Algeria), between January 2020 and December 2022, using a database of 103 papillary thyroid cancer patients. In order to analyze the medical records data, SPSS 22.0 was used. Results: The majority of patients were women (92.2%, mean age 44.16 ± 12.78 years). 43.7% of the studied population had a previous history of thyroid diseases, and 20.4% of them have a family history of thyroid disorders. The majority of patients (91.3%) underwent a total thyroidectomy. Only 17.5% of patients underwent a lymph node dissection. Most patients (73.8%) were diagnosed with the lowest risk of thyroid carcinomas. The number of cancers associated with capsular refraction was low, and none of the patients had any signs of vascular invasion or recurrence.Conclusion: These results provide important information about the epidemiology of papillary thyroid cancer in Northwestern Algeria and can help to identify risk factors and the etiology of the disease. This information can be used to improve the management of patients with papillary thyroid carcinoma and to develop strategies for early detection and prevention of the disease.