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289459

Risk Factors and Clinicopathological Features of Female Breast Cancer Patients: A Retrospective Descriptive Study in Northwestern Algeria

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Last updated: 24 Dec 2024

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Abstract

Background: Constituting the most frequent malignant tumor among women in Algeria, breast cancer represents a heterogeneous and multifactorial disease. The current study aimed to determine the risk factors and clinicopathological features of breast cancer in women from Sidi-Bel-Abbes region, Northwestern Algeria. Patients and Methods: A descriptive retrospective study was carried out by reviewing data from the medical records of patients who underwent a mastectomy at the level of the maternity hospital of Sidi-Bel-Abbes, in the period 2020-2022. Results: Based on 118 breast cancer patients' data records, the mean age at diagnosis was 52.92±13.69 years. Patients with blood group O+ (38.1%) were the most affected. The majority of patients were married women (88.1%). The prevalent disease recorded in patients' medical history was hypertension (23.7%). Further, 45.8% of patients were premenopausal, and 12.7% were nulliparous. The mean age at menarche was 12.47±0.73 years. The most common histological type was invasive ductal carcinoma (77.1%), SBR grade II was mainly found in 65.3% of cases, T2 was the main tumor size (64.4%), and 3.4% of patients had metastatic disease. The expression of estrogen receptors and progesterone receptors was respectively positive in 68.6% and 64.6% of cases. Luminal B was the predominant molecular subtype (55.1%). Conclusion: In our region, breast cancer is mainly diagnosed in younger and middle-aged women at an advanced stage, and numerous risk factors influence breast cancer occurrence. Therefore, Better identification of breast cancer risk factors and the biological mechanisms in which they are involved can be effective in improving breast cancer prevention.

DOI

10.21608/eajbsc.2023.289459

Keywords

breast cancer, risk factor, Clinicopathological features, Women, Algeria

Authors

First Name

Mounira

Last Name

Abdelkaoui

MiddleName

-

Affiliation

Department of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. -Laboratory of Molecular Microbiology, Proteomics and Health, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. epartment of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria

Email

mounira.abdelkaoui@outlook.fr

City

Algeria

Orcid

0000-0002-0420-0259

First Name

Amel

Last Name

Sebaa

MiddleName

-

Affiliation

Department of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. -Laboratory of Molecular Microbiology, Proteomics and Health, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. epartment of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria

Email

sebaamel@yahoo.fr

City

Algeria

Orcid

-

First Name

Siheme

Last Name

Ouali

MiddleName

-

Affiliation

Department of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. -Laboratory of Molecular Microbiology, Proteomics and Health, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. epartment of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria

Email

-

City

Algeria

Orcid

-

First Name

Fadl Allah

Last Name

Abou-Bakr

MiddleName

-

Affiliation

The Obstetric and Gynaecologic Hospitalist, Sidi-Bel-Abbes, Algeria.

Email

fadl_aboubakr@hotmail.fr

City

-

Orcid

-

First Name

Abdenacer

Last Name

Tou

MiddleName

-

Affiliation

Department of Anatomopathology, University Hospital Center, Sidi-Bel-Abbes, Algeria

Email

tou.abdenacer@gmail.com

City

Algeria

Orcid

-

First Name

Boumediene

Last Name

El-Habachi

MiddleName

-

Affiliation

Department of General Surgery, University Hospital Center, Sidi-Bel-Abbes, Algeria

Email

boumediene.elhabachi@yahoo.fr

City

-

Orcid

-

Volume

15

Article Issue

1

Related Issue

38909

Issue Date

2023-06-01

Receive Date

2023-01-28

Publish Date

2023-03-13

Page Start

213

Page End

223

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 15_Issue 1_Pages 213-223.pdf

PDF . 446.2kB

Link

https://eajbsc.journals.ekb.eg/article_289459.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=289459

Order

289,459

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Risk Factors and Clinicopathological Features of Female Breast Cancer Patients: A Retrospective Descriptive Study in Northwestern Algeria

Details

Type

Article

Created At

24 Dec 2024