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Evaluation Effect of the Essential Oil of Green Anis (Pimpinella Anisum) on The Liver Function of Young Rats Following Exposure to Mercury Chloride

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Last updated: 03 Jan 2025

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Abstract

Green anis is a plant known since antiquity with its different therapeutic effects such as; antifungal, antimicrobial, antiviral, analgesic, antioxidant and hepatoprotective effects. However, mercury is a trace element metal that is very common in the environment and has adverse effects on human health. The liver is considered to be the seat of metabolism and the elimination of drugs and exogenous substances from the body.
              This work consists on the one hand evaluating the hepatotoxicity induced in young Wistar rats during the period of development, following exposure to a dose of 100mg/L of mercury chloride. On the other hand, we treated young rats with the essential oil of green anis. On the other hand, we measured the biomarkers of the hepatic function such: ALT, ASAT and ALP followed by a histological study. the results demonstrate a significant increase of these biomarkers in intoxicated animals ASAT, ALAT, ALP (p<0.01), (P < 0.05), (p<0.01) respectively and an alteration of the liver architecture. Nevertheless, we recorded an improvement in these parameters after the treatment with anis oil for 21 days.
               In conclusion, exposure to mercury chloride during the development period induced disruption of liver metabolism by changing serum transaminases levels and liver histology. This could be ameliorated by treatment with the essential oil of Pimpinella anisum.

DOI

10.21608/eajbsc.2023.289198

Keywords

Green anis, mercury, essential oil, liver biomarkers, histology

Authors

First Name

Wafaa

Last Name

Arabi

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological recovery of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria.

Email

wafaaarabi@yahoo.fr

City

Algeria

Orcid

-

First Name

Khaled

Last Name

Kahloula

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological recovery of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria.

Email

kahloulakhaled@yahoo.fr

City

Algeria

Orcid

-

First Name

Djallel Eddine

Last Name

Adli

MiddleName

Houari

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological recovery of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria.

Email

-

City

Algeria

Orcid

-

First Name

Houari

Last Name

Hemida

MiddleName

-

Affiliation

Institue of Veterinary Sciences Ibn-Khaldoun University Tiaret 14000, Algeria.

Email

-

City

Algeria

Orcid

-

First Name

Mostapha

Last Name

Brahmi

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological recovery of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria. -Department of Biology, Faculty of Science and Technology, University of Relizane 48000, Algeria.

Email

mostapha.brahmi20@gmail.com

City

-

Orcid

0000-0003-4131-5802

First Name

Narimane

Last Name

Taibi

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological recovery of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria.

Email

-

City

-

Orcid

-

First Name

Miloud

Last Name

Slimani

MiddleName

-

Affiliation

Laboratory of Biotoxicology, Pharmacognosy and Biological recovery of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria.

Email

mslimani20@gmail.com

City

Algeria

Orcid

-

Volume

15

Article Issue

1

Related Issue

38909

Issue Date

2023-06-01

Receive Date

2023-01-27

Publish Date

2023-03-11

Page Start

205

Page End

212

Print ISSN

2090-0767

Online ISSN

2090-083X

Article File

EAJBSC_Volume 15_Issue 1_Pages 205-212.pdf

PDF . 594.7kB

Link

https://eajbsc.journals.ekb.eg/article_289198.html

Detail API

https://eajbsc.journals.ekb.eg/service?article_code=289198

Order

289,198

Type

Original Article

Type Code

673

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

Publication Link

https://eajbsc.journals.ekb.eg/

MainTitle

Evaluation Effect of the Essential Oil of Green Anis (Pimpinella Anisum) on The Liver Function of Young Rats Following Exposure to Mercury Chloride

Details

Type

Article

Created At

24 Dec 2024