With a very large population and high birth rate, and consanguineous marriage favored in many communities, there is a high prevalence of genetic disorders in India. The cross-sectional study was carried out in people of the Kanyakumari District, Tamil Nadu community males and, females both married and single with a wide range of ages and educational backgrounds as well as covering a diverse number of generic diseases. The cross-sectional survey was conducted among people of the Kanyakumari District, Tamil Nadu (n = 201) to determine their practices toward reproductive decision-making.  The main objective of the study is to analyze the participant's knowledge of the practices towards prenatal diagnosis (PND) and termination of pregnancy. Genetic testing has the maximum possible potential to reduce the prevalence of genetic disorders by early detection. Studies found that general knowledge of genetic diseases in Tamil Nadu lacks an understanding of the fundamental characteristics of genetic diseases. Primarily due to the occurrence of consanguineous marriages 20%. The practice towards PND (61%) was more favorable than TOP (39%). PND was found to be a good opportunity for early diagnosis and gives parents choice.  In Kanyakumari District, most people will have an awareness of genetic disorders, Prenatal diagnosis, and Termination of pregnancy. Mercy (22.60%), religious belief (12.8%), and sin (12.2%) is the main influence on the participant's practices concerning Prenatal diagnosis and Termination of pregnancy. The fetus was diagnosed with a genetic disorder before 120 days of pregnancy, they have undergone abortion favored by 61.2%, and unfavored by 48% of the people.  62% of members responded to the diagnosis of a fetus with genetic diseases before delivery, and 38% were not accepted in prenatal diagnosis. 50.8% of members not knowing the causes of a family history of genetic diseases. But 49.2% know the causes of a family history of genetic diseases.  The reason for rejecting the above question was religious belief (12.8%), Ethics (10.4%), culture (9.8%) Mercy (22.6%), sin (12.2%), Others reason (32.3%). For accepting abortion before 120 days of pregnancy (50.2%) members for getting a healthy child (68.9%), to avoid the affected child (31.1%).  The current challenge of the research is a comprehensive effort to revisit consanguineous marriages and their effects with more recent using statistical methods to assess the prevalence and effect of consanguineous marriages on pregnancy.