Background: Poisoning in elderly people is frequently more severe, with greater complications
and a higher risk of death. This study aimed to explore the risk factors affecting the prognosis
of elderly individuals with acute intoxication. Subjects and Methods: A prospective study
involved all individuals sixty years of age or older with acute intoxication admitted to the Poison
Control Center of Ain Shams University Hospitals during 2022. Results: There were 72 elderly
individuals with acute intoxication were enrolled in this study, with 56 survivors (77.78%) and
16 non-survivors (22.22%). The majority of patients (83.33%) were between 60 and 74 years. Accidental intoxication and suicidal attempts were equally represented. The majority of acutely
intoxicated elderly patients had one or more underlying chronic comorbidities and the oral route
was more common. CVS drugs, CNS drugs, and pesticides were the major causes of acute
poisoning in elderly patients. CVS complications were the most frequent reason of ICU
admission in the elderly patients. The PSS score and APACHE II score were 3 ± 0 and 29.25 ±
3.55 in the non-survivors, 1.52 ± 0.60, and 7.92 ± 1.81 in the survivors. Long hospitalization was
correlated with a high APACHE II score. The presence of respiratory manifestations, the need
for mechanical ventilation, PSS score, and the APACHE II score were the independent risk
factors of poor prognosis. Conclusion: The presence of respiratory manifestations, the need for
mechanical ventilation, the PSS score, and the APACHE II score were the prognostic factors in
elderly patients with acute poisoning. This study recommends taking precautions against
poisoning in the elderly, particularly those who are at a high risk of suicid