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307642

The use of Nicotinamide in Parkinson’s disease; A Possible path to the future. Review Article

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Last updated: 03 Jan 2025

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Abstract

Increasing the prevalence of Parkinson's disease is an alarming sign that needs attention, so focusing on new medications and regimens which play an important role in prevention and treatment becomes a point of concern. Parkinson's disease is the second neurodegenerative disorder caused by the interplay between different mechanisms that are related to genetics, environment, and other factors. One of the potential treatment options under research is nicotinamide which may act as a neuroprotective agent. Although nicotinamide is accepted as a therapeutic agent in many diseases, its action as a Nicotinamide adenine dinucleotide (NAD) precursor against oxidative stress needs to be proved in Parkinson's disease. Here, based on the current literature, we provide a thorough overview of nicotinamide usage in medicine. We summarize chemistry, uses, side effects, different mechanisms, and all available preclinical and clinical data about the activity of nicotinamide. Nicotinamide increases cytoprotection, the release of dopamine, and decreases oxidative stress of mitochondria. As a consequence, we believe that nicotinamide may become a potential drug in the treatment of Parkinson's patients.

DOI

10.21608/aps.2023.204521.1116

Keywords

Parkinson, Cardinal, genes, nicotinamide, Drosophila, neuroprotection

Authors

First Name

Sarah

Last Name

Fahmy

MiddleName

F

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

sarah.farid@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

Alshahawy

MiddleName

-

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

mona.alshahawy@pharma.asu.edu.eg

City

-

Orcid

0000-0001-7424-279

First Name

Nourhan

Last Name

Mohamed

MiddleName

-

Affiliation

Pharm D students, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

nourhanabdraboo@yahoo.com

City

-

Orcid

-

First Name

Nora

Last Name

Gamal

MiddleName

-

Affiliation

Pharm D students, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

nora124134@miuegypt.edu.eg

City

-

Orcid

-

First Name

Samar

Last Name

Abdelazim

MiddleName

-

Affiliation

Pharm D students, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

drsamarabdelazim2@gmail.com

City

-

Orcid

-

First Name

Nadia

Last Name

Abdelsalam

MiddleName

-

Affiliation

Pharm D students, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

nadiaharfoush1996@gmail.com

City

-

Orcid

-

First Name

Hend

Last Name

Abdelrahim

MiddleName

-

Affiliation

Pharm D students, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

hebaelhammadi@gmail.com

City

-

Orcid

-

First Name

Reem

Last Name

Shehab

MiddleName

H

Affiliation

Pharm D students, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

-

City

-

Orcid

-

First Name

Lamia

Last Name

El Wakeel

MiddleName

-

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

lamia.elwakeel@pharma.asu.edu.eg

City

-

Orcid

0000-0003-0250-1709

Volume

7

Article Issue

1

Related Issue

40766

Issue Date

2023-06-01

Receive Date

2023-04-08

Publish Date

2023-06-01

Page Start

147

Page End

170

Print ISSN

2356-8380

Online ISSN

2356-8399

Article File

APS_Volume 7_Issue 1_Pages 147-170.pdf

PDF . 1.4MB

Link

https://aps.journals.ekb.eg/article_307642.html

Detail API

https://aps.journals.ekb.eg/service?article_code=307642

Order

307,642

Type

Review Article

Type Code

658

Publication Type

Journal

Publication Title

Archives of Pharmaceutical Sciences Ain Shams University

Publication Link

https://aps.journals.ekb.eg/

MainTitle

The use of Nicotinamide in Parkinson’s disease; A Possible path to the future. Review Article

Details

Type

Article

Created At

24 Dec 2024